Stand-up comic Max Bernal (Bobby Cannavale) and his 11-year-old autistic son Ezra set off on a road trip in this portrait of a family figuring out how to understand one another. Having recently blown up his career and his marriage, Max is living with his father Stan (Robert De Niro) and is profoundly at odds with his soon-to-be ex-wife Jenna (Rose Byrne) about how to address their son's special needs. When Ezra is expelled from yet another school, Max makes the controversial decision to take Ezra on a cross-country odyssey.