A family has been massacred in their own house, the setting of a grisly crime in small-town Virginia. Hidden in the basement, the partially buried body of a murdered woman is discovered. Drawn into the mysterious case, coroner Tony Tilden (Brian Cox) and his son Austin (Emile Hirsch) conduct an otherwise routine late-night autopsy on the unidentified corpse. But as the night crawls on, the autopsy becomes more complex than they ever imagined and the two men discover less about the victim and more about their own primal fears.