Nikki Grace (Laura Dern), a fading movie star, begins to adopt the persona of her character in a supposedly cursed film production. This leads her down a worrisome and dissociative path which begins to wreak havoc on her reality. In exploring a contaminated Hollywood, a physical Los Angeles and a metaphorical America, director David Lynch traverses the realm of the mind in a surreal work that is as beguiling as it is confounding.