Set in a near-future Seattle teetering on the brink of calamity, in the midst of a global epidemic: Neuroinflammatory Affliction, a severe and rapid Alzheimer's-like condition in which people's memories disappear. Young couple Jude Williams (Jack O'Connell) and Emma Ryerson (Olivia Cooke) are grappling with the realities of NIA, interspersed with glimpses from the past as the two meet and their relationship blooms. But as NIA's grip on society tightens, blurring the lines between the past and the present, it becomes more and more difficult to know what's true and what's false.